Syrup and Suspensions

Non-sterile plant, yet with the same high-quality standards of sterile process

  • Powder loading

    A complete system to easily lift and load sugar

  • High shear mixer
    and divert valves

    Mixing and manage powder flux as basic steps of the process

  • Holding area

    Four large-capacity fixed tanks, with transfer pumping mixer and CIP return pumps

  • Complete Solutions

    Syrup and Suspension process plant is usually designed following exactly the same high-quality standards as for sterile process, in order to ensure compliance with GMP standards for customers too.

    Manufacturers tend to produce syrup on their own, as this allows to have better control of final product. Syrup is produced by blending the API with water, sweeteners, flavour concentrates and minor excipients. 

    On the other side, aqueous suspension preparations for injection are often a water-insoluble local anesthetic and/or narcotic analgesic in form of particles. In suspension, sedimentation and agglomeration of particles of active agents can occur, thus leading to clogging of injection needles or catheters.

    The use of in-line homogenizer and mixer becomes essential during the process to ensure dissolution of the sugar in syrup preparation and to maintain the suspension stable.

  • Explore

    What differentiates syrup and suspension is that the first is a solution where sugar is quite swiftly dissolved in other solvents, while the suspension is a biphasic liquid system which contains insoluble particles in the liquid medium. The active principle is therefore soluble in syrup, while suspension keeps solid particles in the liquid phase.

    During manufacturing process is fundamental to properly hydrate powdered ingredients and dissolve sugars to form the syrup, avoiding crystallization and damage of API while cooling/heating.

    Pharmaceutical suspensions instead are liquid dosage containing insoluble particles suspended in the medium. Their production involves multiple steps, starting from the procedure to obtain particles in the micrometer range and then the addition of necessary adjuvants.