Spray, Aerosol and Ophthalmic

A process plant for MDI production

• Propellant distribution line

  To receive and delivery HFA to the propellant filling line

• Process twin bulk

  Two twin preparation bulks

• Storage system for ethanol and HFA

  External area to store flammable materials

• Complete Solutions

  The plant is designed to produce metered-dose inhalers (MDIs).
  It is structured into several rooms: a room for the twin process bulks, a room to store and distribute glycerol, an outdoor area for ethanol and propellant storage, and a room where have been placed clean utilities for PW production.

• Explore

  The MDI device consists of a canister, an actuator and sometimes a spacer. The formulation, made up of the drug, liquefied gas propellant and stabilizing excipients resides in the canister. By activation, the volatile propellant breaks up into droplets which then evaporate, creating an aerosol containing micronized drug that is inhaled into the lungs. Pharmaceutical aerosols are pressurized dosage forms containing one or more active ingredients which upon activation emit a fine dispersion of liquid and/or solid materials in a gaseous medium. Aerosols are used to administer drugs to the lungs especially to treat respiratory conditions.
  Pharmaceutical sprays are administered orally or nasally through respiration. In sprays, a liquid or solid formulation is converted into a dynamic mixture dispersed in gas through atomization.
  Sterility is essential for ophthalmic formulations. Ophthalmic formulation must be carefully balanced to ensure adequate bioavailability and minimal irritation. They take the form of suspensions, ointments, solutions, or emulsions.