Cytotoxic Anticancer

Handle sensitive, hazardous, yet fundamental drugs

• Excipients and Lipid production zone

  Two zones to produce excipients that will surround the cytotoxic active ingredient

• Isolator and Heating-Cooling group

  Loading the active principle safely. Heat and cold to shape the drug.

• Filtration unit and sterile holding tanks

  To keep the sterility of the final product

• Complete Solutions

  Cytotoxic process plants require extra care in the design: each component of the plant has to be compliant with GMP regulations, therefore ensure protection for operators and for the surrounding environment. Indeed, cytotoxic drugs act by inhibiting or preventing the function of cells, stopping their replication or growth. They are primarily used to treat cancer and other diseases. This drug category is not able to generate action tightly targeted on tumoral cells and attack healthy cells too, thus it can produce side effects both to the patients and operators exposed.

  The isolator so becomes a fundamental part of the plant: designed to handle liquid with cytotoxic compounds, it offers an effective barrier to protect operator, product and environment from hazards caused by uncontrolled diffusion of air-transported contaminants. At the same time, it avoids any biological interference of the environment on the product during its handling.

• Explore

  The final product produced in this plant is classified as antibiotic antineoplastic and it’s given by injection through vein.

  The main characteristic of the product is that the drug is encapsulated in a STEALTH® liposome.  Liposomes are closed lipid spheres made of the basic components of natural human cell walls. This kind of liposome is protected on the surface by a substance that inhibits its detection by the body’s immune system. The drug can therefore increase the time of circulation in the blood.  Studies have shown this type of drug is able to get closer to the tumor; liposomes indeed are the perfect drug delivery systems, as they can move from the blood compartment into the extravascular space surrounding the tumor cells, providing locally concentrated drug delivery.